a Record control number 000253644300001

a ISSN 0892-3973

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QW504

b Item number .M93 2008

a Personal name Akkoç, Tunç.

h Medium Electronic Document

a Title Mycobacterium vaccae immunization to OVA sensitized pregnant BALB/c mice suppressed placental and postnatal IL-5 and inducing IFN-gamma secretion.

c Statement of responsibility, etc Tunc Akkoc, Nerin N. Bahceciler, Isil B. Barlan, Aarif O. Eifan, Cevdet Ozdemir, Didem Yazi, Ozlem Yesil, Nerin N. Bahceciler, Isil B. Barlan.

b Name of publisher, distributor, etc Taylor & Francis Inc.,

c Date of publication, distribution, etc 2008.

a Summary, etc Although the development of atopy in the newborn is determined by a multitude of factors, an intense Th1 stimulus early in life could be protective by facilitating a switch away from Th2. Aimed to determine the effect of single Mycobacterium vaccae (M. vaccae) immunization to OVA-sensitized pregnant mice on IL-5 and IFN-gamma secretion from placental lymphocytes and splenocytes of offspring. Pregnant BALB/c mice were divided into 4 groups, OVA-sensitized + M. vaccae immunized, OVA-sensitized, M. vaccae immunized and controls. Sensitization with OVA was initiated before mating, and aerosol OVA challenge were performed during pregnancy. M. vaccae immunization was performed on the 12(th) day of pregnancy. IL-5 and IFN-gamma levels of placental lymphocytes were analyzed on the 18(th) day of pregnancy and splenocytes of offspring on the 2(nd) and 28(th) days during postnatal period. A single administration of M. vaccae to OVA-sensitized pregnant mice downregulated IL-5 secretion and induced IFN-gamma secretion from placental lymphocytes. On the other hand, after M. vaccae immunization downregulation of IL-5 levels and upregulation of IFN-gamma secretion persisted in offspring when determined on 2(nd) and 28(th) days of life. Vaccination with M. Vaccae to OVA-sensitized pregnant BALB/c mice prevented Th2 immune responses by enhancing secretion of IFN-gamma and lowering IL-5 levels during pregnancy and the effect persisted during the postnatal period in offspring.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Immunology

a Topical term or geographic name as entry element Pharmacology & Pharmacy

a Topical term or geographic name as entry element Hygiene hypothesis

g Relationship information 2008, Vol. 30 Issue 1, p1-11

t Title Immunopharmacology And Immunotoxicology

x International Standard Serial Number 08923973

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1080/08923970701812159